Circulating Microbial Products and Acute Phase Proteins as Markers of Pathogenesis in Lymphatic Filarial Disease
Identifieur interne : 004448 ( Main/Exploration ); précédent : 004447; suivant : 004449Circulating Microbial Products and Acute Phase Proteins as Markers of Pathogenesis in Lymphatic Filarial Disease
Auteurs : R. Anuradha [Inde] ; P. Jovvian George [Inde] ; N. Pavan Kumar [Inde] ; Michael P. Fay [États-Unis] ; V. Kumaraswami [Inde] ; Thomas B. Nutman [États-Unis] ; Subash Babu [Inde, États-Unis]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Cytokines (sang), Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (sang), Glycoprotéines membranaires (sang), Humains, Jeune adulte, Lipopolysaccharides (sang), Marqueurs biologiques (sang), Mâle, Protéine de la phase aigüe (analyse), Protéines de transport (sang).
- MESH :
- analyse : Protéine de la phase aigüe.
- immunologie : Filariose lymphatique.
- sang : Cytokines, Filariose lymphatique, Glycoprotéines membranaires, Lipopolysaccharides, Marqueurs biologiques, Protéines de transport.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Acute-Phase Proteins.
- chemical , blood : Biomarkers, Carrier Proteins, Cytokines, Lipopolysaccharides, Membrane Glycoproteins.
- blood : Elephantiasis, Filarial.
- immunology : Elephantiasis, Filarial.
- Adult, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients. Dysregulated host inflammatory responses leading to systemic immune activation are thought to play a central role in filarial disease pathogenesis. We measured the plasma levels of microbial translocation markers, acute phase proteins, and inflammatory cytokines in individuals with chronic filarial pathology with (CP Ag+) or without (CP Ag−) active infection; with clinically asymptomatic infections (INF); and in those without infection (endemic normal [EN]). Comparisons between the two actively infected groups (CP Ag+ compared to INF) and those without active infection (CP Ag− compared to EN) were used preliminarily to identify markers of pathogenesis. Thereafter, we tested for group effects among all the four groups using linear models on the log transformed responses of the markers. Our data suggest that circulating levels of microbial translocation products (lipopolysaccharide and LPS-binding protein), acute phase proteins (haptoglobin and serum amyloid protein-A), and inflammatory cytokines (IL-1β, IL-12, and TNF-α) are associated with pathogenesis of disease in lymphatic filarial infection and implicate an important role for circulating microbial products and acute phase proteins.
Url:
DOI: 10.1371/journal.ppat.1002749
PubMed: 22685406
PubMed Central: 3369944
Affiliations:
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Dysregulated host inflammatory responses leading to systemic immune activation are thought to play a central role in filarial disease pathogenesis. We measured the plasma levels of microbial translocation markers, acute phase proteins, and inflammatory cytokines in individuals with chronic filarial pathology with (CP Ag+) or without (CP Ag−) active infection; with clinically asymptomatic infections (INF); and in those without infection (endemic normal [EN]). Comparisons between the two actively infected groups (CP Ag+ compared to INF) and those without active infection (CP Ag− compared to EN) were used preliminarily to identify markers of pathogenesis. Thereafter, we tested for group effects among all the four groups using linear models on the log transformed responses of the markers. Our data suggest that circulating levels of microbial translocation products (lipopolysaccharide and LPS-binding protein), acute phase proteins (haptoglobin and serum amyloid protein-A), and inflammatory cytokines (IL-1β, IL-12, and TNF-α) are associated with pathogenesis of disease in lymphatic filarial infection and implicate an important role for circulating microbial products and acute phase proteins.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Nutman, Tb" uniqKey="Nutman T">TB Nutman</name></author><author><name sortKey="Kumaraswami, V" uniqKey="Kumaraswami V">V Kumaraswami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dreyer, G" uniqKey="Dreyer G">G Dreyer</name></author><author><name sortKey="Noroes, J" uniqKey="Noroes J">J Noroes</name></author><author><name sortKey="Figueredo Silva, J" uniqKey="Figueredo Silva J">J Figueredo-Silva</name></author><author><name sortKey="Piessens, Wf" uniqKey="Piessens W">WF Piessens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Almeida, Ab" uniqKey="De Almeida A">AB de Almeida</name></author><author><name sortKey="Freedman, Do" uniqKey="Freedman D">DO Freedman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steel, C" uniqKey="Steel C">C Steel</name></author><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author><author><name sortKey="Weller, Pf" uniqKey="Weller P">PF Weller</name></author><author><name sortKey="Nutman, Tb" uniqKey="Nutman T">TB Nutman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babu, S" uniqKey="Babu S">S Babu</name></author><author><name sortKey="Anuradha, R" uniqKey="Anuradha R">R Anuradha</name></author><author><name sortKey="Pavan Kumar, N" uniqKey="Pavan Kumar N">N Pavan Kumar</name></author><author><name sortKey="George, Pj" uniqKey="George P">PJ George</name></author><author><name sortKey="Kumaraswami, V" uniqKey="Kumaraswami V">V Kumaraswami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babu, S" uniqKey="Babu S">S Babu</name></author><author><name sortKey="Bhat, Sq" uniqKey="Bhat S">SQ Bhat</name></author><author><name sortKey="Pavan Kumar, N" uniqKey="Pavan Kumar N">N Pavan Kumar</name></author><author><name sortKey="Lipira, Ab" uniqKey="Lipira A">AB Lipira</name></author><author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfarr, Km" uniqKey="Pfarr K">KM Pfarr</name></author><author><name sortKey="Debrah, Ay" uniqKey="Debrah A">AY Debrah</name></author><author><name sortKey="Specht, S" uniqKey="Specht S">S Specht</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freedman, Do" 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P">PS Abdul-Rahman</name></author><author><name sortKey="Wan Ibrahim, Wi" uniqKey="Wan Ibrahim W">WI Wan-Ibrahim</name></author><author><name sortKey="Hashim, Oh" uniqKey="Hashim O">OH Hashim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walzl, G" uniqKey="Walzl G">G Walzl</name></author><author><name sortKey="Ronacher, K" uniqKey="Ronacher K">K Ronacher</name></author><author><name sortKey="Hanekom, W" uniqKey="Hanekom W">W Hanekom</name></author><author><name sortKey="Scriba, Tj" uniqKey="Scriba T">TJ Scriba</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Inde</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="Inde"><noRegion><name sortKey="Anuradha, R" sort="Anuradha, R" uniqKey="Anuradha R" first="R." last="Anuradha">R. Anuradha</name></noRegion><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name><name sortKey="George, P Jovvian" sort="George, P Jovvian" uniqKey="George P" first="P. Jovvian" last="George">P. Jovvian George</name><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name><name sortKey="Pavan Kumar, N" sort="Pavan Kumar, N" uniqKey="Pavan Kumar N" first="N." last="Pavan Kumar">N. Pavan Kumar</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Fay, Michael P" sort="Fay, Michael P" uniqKey="Fay M" first="Michael P." last="Fay">Michael P. Fay</name></region><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. 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